Title of Research Project:
Understanding how an anti-cancer drug targets breast, ovarian, and endometrial cancers
Recently, a novel anti-cancer drug, BHPI, was discovered that works in an exciting way, by causing necrotic cell death, or cellular explosion. Surprisingly, this drug is able to target and kill breast, ovarian, and endometrial cancer cells that express the protein Estrogen Receptor alpha (ERŒ±), and that are resistant to standard chemotherapy drugs. We are interested in understanding how this anti-cancer drug works at the cellular level. In this project, we will look at how this drug stalls the cancer cells recycling system and how this stalling contributes to necrotic cell death.
If there is important prerequisite knowledge/skills required for students, please describe below:
An interest in molecular and cancer biology