Kagey, Dr. Jacob

Research Project: The use of Drosophila melanogaster to study cell growth and cell division
Prerequisite: A good foundation of classical genetics
Description: In my lab we utilize the fruit fly (Drosophila melanogaster) to study the genetic regulation of cell growth and cell division, two molecular pathways often disrupted in human cancer.The developing eye of Drosophila melanogaster provides a model in which to study Yorkie signaling in cell survival, cell division, and cell differentiation and specification. Controlled genetic crosses can target the disruption of Yorkie at different times and locations within the developing eye and the resulting phenotypic changes can be studied. This will provide a mechanism to study how the translocation of a single protein can affect three vey different developmental processes in the same developing tissue. This knowledge can help to better understand the role of Yap1/2 (human Yorkie) activation in human genetic disorders.