Kagey, Dr. Jacob

Title of Research Project:

Using Drosophila melanogaster to identify novel regulators of cell growth and cell division

Research Description:

We utilize Drosophila melanogaster (fruit flies) to identify mutations that alter the regulation of cell growth and division in developing flies, which are processes that are often altered in human cancers. To study these mutations, we focus on the Drosophila eye and wing, two different non-essential epithelial tissues. Understanding what causes tissues to overgrow in fruit flies can be used to help understand the mechanisms involved in human carcinogenesis. Currently, we have a number of projects focusing on different biological pathways including known cancer-related pathways such as Hippo , Hedgehog, Notch, and Dpp.

If there is important prerequisite knowledge/skills required for students, please describe below:

Fundamentals of Genetics

If working with another faculty member, please include their name below:

Collaborations with Stephanie Conant (UDM) and Tiffany Cook (WSU)