Najor, Dr. Nicole

Title of Research Project:

Understanding Ubiquitin ligases in Skin Development

Research Description:

The epidermis, the outermost layer of skin, serves as a critical barrier against the outside environment. A common feature among epithelial tissues is the proper maintenance and formation of cell junctional protein complexes. Desmosomes are a type of cell-cell junctional protein complex that have been shown to interact with the COP9 signalosome (Constitutively Photomorphogenic). The desmosome-COP9 complex has been shown to downregulated epidermal growth factor receptor (EGFR), which is a known signaling player in cell growth. While the desmosome-COP9 signalosome super-complex functions have been well defined for the maintenance of skin homeostasis, its interacting cullin ubiquitin ligases have not yet been explored. Through targeted protein analysis in a variety of epithelial cells lines, this research aims to identify and clarify the process by which the cullin ubiquitin ligases contributes to novel epithelial cell signaling.

If there is important prerequisite knowledge/skills required for students, please describe below:


If working with another faculty member, please include their name below: