Friedrich, Dr. Klaus

Research Project: Allosteric Modulators for mGluR5
Prerequisite: An interest in the synthesis and testing of biological molecules.
Description: Metabotropic glutamate receptors (mGluRs) are involved in numerous cellular processes ranging from neuronal development to the processing of cognitive, motor and sensory information. Several neurological and psychiatric disorders like Fragile-X syndrome, Parkinson’s Disease, addiction, depression, and schizophrenia have been linked to derailed signaling pathways associated with mGluRs. Due to the therapeutic benefits of targeting allosteric binding sites of these receptors, a synthetic pathway to new mGluR5 negative allosteric modulator (NAM) chemotypes is being investigated. A new scaffold has been designed. A balance of physico-chemical properties required to penetrate the CNS, careful spatial arrangement of substituents, and metabolic innocuousness are considered in the design.